These animal studies provided conflicting results. Only 7 animal studies (1 mouse, 4 rat, and 2 pig) were relevant to the proposed question. No human studies met the inclusion criteria. Outcomes included mortality, wound healing, speed of re-epithelialization, and infection rates.įor burns, our search revealed 400 potential articles. We considered trials that enrolled patients of any age with partial-thickness burns or venous stasis ulcers and randomized them to either topical SSD or placebo, saline-soaked gauze, paraffin gauze, sterile dry dressing, or nonantibiotic moist dressing. MEDLINE, EMBASE, Cochrane Library, and other databases were searched. This evidence-based review intends to answer the following research question: in ambulatory patients with partial-thickness burns or stasis dermatitis ulcers, does the use of topical SSD compared with nonantibiotic dressings improve mortality, wound healing, re-epithelialization, or infection rates? Much of these costs come from treating prolonged and severe ulceration.For decades silver-containing antibiotics such as silver sulfadiazine (SSD) have been applied as standard topical therapy for patients with partial-thickness burns and venous stasis ulcers. Diabetic foot care accounts for more healthcare costs in England than breast, prostate and lung cancer combined. Of this, 80% is spent on treating complications, and diabetic foot care is estimated to cost the NHS in England over £1 billion per year. The NHS spends at least £10 billion a year on diabetes, equivalent to 10% of its budget. Although people of South Asian, African and African Caribbean family origin are more at risk of diabetes, there is no evidence that the prevalence of diabetic foot ulceration and amputation is higher in these subgroups than in the general population of people with diabetes in the UK.įoot problems in people with diabetes have a significant financial impact on the NHS through primary care, community care, outpatient costs, increased bed occupancy and prolonged stays in hospital. This high mortality rate is believed to be associated with cardiovascular disease, and emphasises the importance of good diabetic and cardiovascular risk management. Mortality rates after diabetic foot ulceration and amputation are high, with up to 70% of people dying within 5 years of having an amputation and around 50% dying within 5 years of developing a diabetic foot ulcer. After a first amputation, people with diabetes are twice as likely to have a subsequent amputation as people without diabetes. People are at higher risk of diabetes-related major and minor limb amputations if they are male, from the most deprived areas, aged over 65, or of white European family background. More than 7,000 diabetes-related amputations are reported in the UK per year. A foot ulcer can be defined as a localised injury to the skin and/or underlying tissue, below the ankle, in a person with diabetes.ĭiabetes is the most common cause of non-traumatic limb amputation, with diabetic foot ulcers preceding more than 80% of amputations in people with diabetes. It is estimated that 10% of people with diabetes will have a diabetic foot ulcer at some point in their lives. For more information, see the NICE guideline on peripheral arterial disease.įoot complications are common in people with diabetes. Peripheral arterial disease affects 1 in 3 people with diabetes over the age of 50 and can also increase the risk of heart attack and stroke. The risk of foot problems in people with diabetes is increased, largely because of either diabetic neuropathy (nerve damage or degeneration) or peripheral arterial disease (poor blood supply due to diseased large- and medium-sized blood vessels in the legs), or both. The life expectancy of people with diabetes is shortened by up to 15 years, and 75% die of macrovascular complications. In England, the number of people diagnosed with diabetes increased between 20 from 1.9 million to 3.3 million. ![]() By 2030, it is estimated that more than 5.5 million people in the UK will have diabetes. Around 90% of these people have type 2 diabetes, around 8% have type 1 diabetes, and about 2% have rarer types of diabetes. More than 4.9 million people in the UK have diabetes. Diabetes is one of the most common chronic diseases in the UK and its prevalence is increasing.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |